What are long term effects of stress on your physical health? We can categorize it based on which areas of your body it affects. The below diagram shows how stress affects human body. Lets start with your head and brain: you may experience depression, headaches, anxiety and increased stroke risk. You are more likely to catch a cold or a flu, or even the new coronavirus covid. Stress also increases your blood pressure, thus increasing risk of a heart attack. You may experience weight gain or loss, muscle pain, and sexual problems. Lowering stress in your life can help reduce the risk of the above conditions and symptoms.